The Development of Congestive Cardiac Failure in a Patient with Hairy Cell Leukemia Treated with 2-Chlorodeoxyadenosine

Deoxyadenosines are closely related to adenosine and as such, may interfere with the cardiac adenylate cyclase pathway resulting in cardiac dysfunction. We report a rare case of a 42 year old man who developed transient cardiac failure following treatment with 2-CDA for hairy cell leukemia.

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Bibliographic Details
Published in:Leukemia & lymphoma 1997, Vol.26 (3-4), p.413-415
Main Authors: Koczwara, Bogda, Spangenthal, Edward, Bernstein, Steven H.
Format: Article
Language:English
Subjects:
2-chlorodeoxyadenosine
Adult
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
cardiac failure
Cladribine - adverse effects
Cladribine - therapeutic use
hairy cell leukemia
Heart Failure - chemically induced
Humans
Leukemia, Hairy Cell - complications
Leukemia, Hairy Cell - drug therapy
Male
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Description
Summary:Deoxyadenosines are closely related to adenosine and as such, may interfere with the cardiac adenylate cyclase pathway resulting in cardiac dysfunction. We report a rare case of a 42 year old man who developed transient cardiac failure following treatment with 2-CDA for hairy cell leukemia.
ISSN:1042-8194
1029-2403
DOI:10.3109/10428199709051794