Effects of nitric oxide on blood flow distribution and O2 extraction capabilities during endotoxic shock

• Published in: Journal of applied physiology (1985) 1997-10, Vol.83 (4), p.1164
• Main Authors: Zhang, Haibo, Rogiers, Peter, Smail, Nadia, Cabral, Ana, Preiser, Jean-Charles, Peny, Marie-Odile, Vincent, Jean-Louis
• Format: Article
• Language: English
• Subjects: Animals; Blood Pressure - drug effects; Blood Pressure - physiology; Cardiac Output - drug effects; Cardiac Output - physiology; Cardiac Tamponade - metabolism; Cardiac Tamponade - physiopathology; Dogs; Endotoxins - toxicity; Enzyme Inhibitors - pharmacology; Molsidomine - analogs & derivatives; Molsidomine - pharmacology; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - biosynthesis; Nitric Oxide - physiology; Nitric Oxide Synthase - antagonists & inhibitors; omega-N-Methylarginine - pharmacology; Oxygen Consumption - drug effects; Oxygen Consumption - physiology; Regional Blood Flow - drug effects; Regional Blood Flow - physiology; Shock, Septic - metabolism; Shock, Septic - physiopathology; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors; Vascular Resistance - drug effects; Vascular Resistance - physiology
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1997.83.4.1164

Haibo Zhang 1 , Peter Rogiers 1 , Nadia Smail 1 , Ana Cabral 1 , Jean-Charles Preiser 1 , Marie-Odile Peny 2 , and Jean-Louis Vincent 1 1  Department of Intensive Care, and 2  Department of Pathology, Erasme University Hospital, Free University of Brussels, B-1070 Brussels, Belgium Received 14 January 1997; accepted in final form 2 June 1997. Zhang, Haibo, Peter Rogiers, Nadia Smail, Ana Cabral, Jean-Charles Preiser, Marie-Odile Peny, and Jean-Louis Vincent. Effects of nitric oxide on blood flow distribution and O 2 extraction capabilities during endotoxic shock. J. Appl. Physiol. 83(4): 1164-1173, 1997. The effects of the nitric oxide (NO) synthase inhibitor N G -monomethyl- L -arginine ( L -NMMA) and the NO donor 3-morpholinosydnonimine (SIN-1) were tested in 18 endotoxic dogs. L -NMMA infusion (10 mg · kg 1 · h 1 ) increased arterial and pulmonary artery pressures and systemic and pulmonary vascular resistances but decreased cardiac index, left ventricular stroke work index, and blood flow to the hepatic, portal, mesenteric, and renal beds. SIN-1 infusion (2 µg · kg 1 · min 1 ) increased cardiac index; left ventricular stroke work index; and hepatic, portal, and mesenteric blood flow. It did not significantly influence arterial and pulmonary artery pressures but decreased renal blood flow. The critical O 2 delivery was similar in the L -NMMA group and in the control group (13.3 ± 1.6 vs. 12.8 ± 3.3 ml · kg 1 · min 1 ) but lower in the SIN-1 group (9.1 ± 1.8 ml · kg 1 · min 1 , both P