Three-dimensional Computer-reconstructed Image for Studying Cancer Extension Within the Hypopharynx

Hypopharyngeal cancer is one of the head and neck cancers with poor prognosis. This is due to the unpredictable extension of the local disease and the high ratio of distant metastasis. To verify the morphological behavior of hypopharyngeal cancer, whole-mount horizontal serial sections were develope...

Full description

Saved in:
Bibliographic Details
Published in:Acta oto-laryngologica 1997, Vol.117 (5), p.764-768
Main Authors: Nakayama, Meijin, Takahashi, Hiroomi, Okamoto, Makito, Yao, Kazuo, Makoshi, Tomohiro, Suzuki, Tatsutoshi
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Carcinoma, Squamous Cell - pathology
Humans
hypopharyngeal cancer
Hypopharyngeal Neoplasms - pathology
Image Processing, Computer-Assisted
Investigative techniques, diagnostic techniques (general aspects)
lymphatic permeation
Male
Medical sciences
Middle Aged
Miscellaneous. Technology
Neoplasm Invasiveness
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
three-dimensional reconstruction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypopharyngeal cancer is one of the head and neck cancers with poor prognosis. This is due to the unpredictable extension of the local disease and the high ratio of distant metastasis. To verify the morphological behavior of hypopharyngeal cancer, whole-mount horizontal serial sections were developed using the larynges obtained from total pharyngolaryngoesophagotomy. The technique of processing high-resolution three-dimensional (3D) images of the larynges using Nikon Cosmozone 2SA software is presented. Two representative surgical specimens were used and 3D images reconstructed. In these two particular cases, the cancer infiltrated superiorly through submucosal lymphatic ducts and formed separate daughter nests under the intact mucosal epithelium far above the main tumor. 3D images enhanced the morphological features of these cases. These cases also suggested the difficulty of defining the upper resecting limit in the operation of hypopharyngeal cancer. 3D reconstruction is and will be a crucial modality for studying the morphological behavior of hypopharyngeal cancer.
ISSN:0001-6489
1651-2251
DOI:10.3109/00016489709113475