Final height in girls with slowly progressive untreated central precocious puberty

A group of six girls with slowly progressive idiopathic precocious puberty (IPP) and a good initial height prognosis was followed without treatment. At first observation the girls had a bone age advance over chronological age of no more than 18 months, a Δheight age (ΔHA):Δbone age (ΔBA) ratio highe...

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Bibliographic Details
Published in:Gynecological endocrinology 1997, Vol.11 (5), p.301-305
Main Authors: Ghirri, P., Bottom, U., Gasperi, M., Bemardini, M., Coccoli, L., Giovanelt, R., Boldrini, A.
Format: Article
Language:English
Subjects:
Age Determination by Skeleton
Aging
Body Height
Central Precocious Puberty
Child
Female
Final Height
Follicle Stimulating Hormone - blood
Gnrh Agonists
Humans
Luteinizing Hormone - blood
Ovary - diagnostic imaging
Prognosis
Puberty, Precocious - blood
Puberty, Precocious - diagnosis
Slowly Progressive Precocious Puberty
Treatment Of Precocious Puberty
Ultrasonography
Uterus - diagnostic imaging
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Summary:A group of six girls with slowly progressive idiopathic precocious puberty (IPP) and a good initial height prognosis was followed without treatment. At first observation the girls had a bone age advance over chronological age of no more than 18 months, a Δheight age (ΔHA):Δbone age (ΔBA) ratio higher than 0.9 and height prognosis was unimpaired after 6 months. During the first two years of follow-up the girls maintained an acceptable height potential. The ΔHA:ΔBA ratio remained constant at greater than 0.9. Predicted height showed a slight increase or decrease (± 4 cm). The girls were reevaluated after the age of14 years and followed-up until they reached their final height (FH). The mean FH(155.4±2.8 cm) was below the mean target height (159.3 ± 4.2 cm) by 3.9 cm (range -2.1 to -6.7 cm); this difference was not statistically significant. The FH was more than 5 cm below the target height in only one case; this girl had the most precocious onset of puberty, at 6 years of age. In three cases FH was between the 3rd and 10th centiles. These three girls had a target height below 158 cm (< 25th centile). Girls with slowly progressive IPP and a good initial height prognosis preserved height potential with an acceptable final height without therapy.
ISSN:0951-3590
1473-0766
DOI:10.3109/09513599709152552