Glutamate Transporter Currents in Bergmann Glial Cells Follow the Time Course of Extrasynaptic Glutamate

Glutamate transporters in the central nervous system are expressed in both neurons and glia, they mediate high affinity, electrogenic uptake of glutamate, and they are associated with an anion conductance that is stoichiometrically uncoupled from glutamate flux. Although a complete cycle of transpor...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1997-12, Vol.94 (26), p.14821-14825
Main Authors: Bergles, D E, Dzubay, J A, Jahr, C E
Format: Article
Language:English
Subjects:
Amino acid transport system XAG
AMPA receptors
Animals
Anions
Biochemistry
Biological Sciences
Biological Transport
Brain
Carrier Proteins - physiology
Cells, Cultured
Glutamic Acid - physiology
Kinetics
Neuroglia
Neuroglia - physiology
Neurology
Neurons
Patch-Clamp Techniques
Pipettes
Proteins
Purkinje cells
Rats
Receptors
Rodents
Synapses
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Summary:Glutamate transporters in the central nervous system are expressed in both neurons and glia, they mediate high affinity, electrogenic uptake of glutamate, and they are associated with an anion conductance that is stoichiometrically uncoupled from glutamate flux. Although a complete cycle of transport may require 50-100 ms, previous studies suggest that transporters can alter synaptic currents on a much faster time scale. We find that application of L-glutamate to outside-out patches from cerebellar Bergmann glia activates anion-potentiated glutamate transporter currents that activate in
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.94.26.14821