Changes in Immunological and Neuronal Conditions Markedly Altered Antibody Response to Intracerebroventricularly Injected Ovalbumin in the Rat

The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune r...

Full description

Saved in:
Bibliographic Details
Published in:Neuroimmunomodulation 1997-07, Vol.4 (4), p.181-187
Main Authors: Kovačeviç-Jovanoviç, Vesna, Laban, Olgica, Stanojeviç, Stanislava, Miletiç, Tatjana, Dimitrijeviç, Mirjana, Raduloviç, Jelena
Format: Article
Language:English
Subjects:
Animals
Antibody Formation - drug effects
Bordetella pertussis - immunology
Brain Injuries - immunology
Freund's Adjuvant - pharmacology
Immunization
Injections, Intravenous
Injections, Intraventricular
Male
Neurons - drug effects
Original Paper
Ovalbumin - immunology
Ovalbumin - pharmacology
Rats
Rats, Wistar
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune response. Central nervous system (CNS) immunization under the conditions of disrupted blood-brain barrier decreased anti-OA antibody production. Peripheral polyclonal stimulation with Bordetella pertussis increased production of specific antibodies to i.c.v. injected antigen, while complete Freund's adjuvant had no effect on the immune response. These results suggest that CNS compartmentalization of antigen may be critical for mounting strong antibody production, and that peripheral polyclonal stimulation of the immune system may markedly contribute to the overall intensity of the immune response.
ISSN:1021-7401
1423-0216
DOI:10.1159/000097336