Changes in Immunological and Neuronal Conditions Markedly Altered Antibody Response to Intracerebroventricularly Injected Ovalbumin in the Rat

The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune r...

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Published in:Neuroimmunomodulation 1997-07, Vol.4 (4), p.181-187
Main Authors: Kovačeviç-Jovanoviç, Vesna, Laban, Olgica, Stanojeviç, Stanislava, Miletiç, Tatjana, Dimitrijeviç, Mirjana, Raduloviç, Jelena
Format: Article
Language:English
Subjects:
Animals
Antibody Formation - drug effects
Bordetella pertussis - immunology
Brain Injuries - immunology
Freund's Adjuvant - pharmacology
Immunization
Injections, Intravenous
Injections, Intraventricular
Male
Neurons - drug effects
Original Paper
Ovalbumin - immunology
Ovalbumin - pharmacology
Rats
Rats, Wistar
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container_end_page 187
container_issue 4
container_start_page 181
container_title Neuroimmunomodulation
container_volume 4
creator Kovačeviç-Jovanoviç, Vesna
Laban, Olgica
Stanojeviç, Stanislava
Miletiç, Tatjana
Dimitrijeviç, Mirjana
Raduloviç, Jelena
description The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune response. Central nervous system (CNS) immunization under the conditions of disrupted blood-brain barrier decreased anti-OA antibody production. Peripheral polyclonal stimulation with Bordetella pertussis increased production of specific antibodies to i.c.v. injected antigen, while complete Freund's adjuvant had no effect on the immune response. These results suggest that CNS compartmentalization of antigen may be critical for mounting strong antibody production, and that peripheral polyclonal stimulation of the immune system may markedly contribute to the overall intensity of the immune response.
doi_str_mv 10.1159/000097336
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source Karger_医学期刊
subjects Animals
Antibody Formation - drug effects
Bordetella pertussis - immunology
Brain Injuries - immunology
Freund's Adjuvant - pharmacology
Immunization
Injections, Intravenous
Injections, Intraventricular
Male
Neurons - drug effects
Original Paper
Ovalbumin - immunology
Ovalbumin - pharmacology
Rats
Rats, Wistar
title Changes in Immunological and Neuronal Conditions Markedly Altered Antibody Response to Intracerebroventricularly Injected Ovalbumin in the Rat
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