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Aspirin-induced Gastritis, Like Helicobacter pylori-induced Gastritis, Disinhibits Acid Secretion in Humans: Relation to Cytokine Expression

Background: Helicobacter pylori infection contributes to hypergastrinemia and hypersecretion of acid by blocking inhibitory reflex pathways to gastrin and parietal cells normally activated by antral distention. Our aim was to investigate whether a similar blockade of inhibitory responses could be pr...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 1998, Vol.33 (4), p.346-356
Main Authors: HAMLET, A, LINDHOLM, C, NILSSON, O, OLBE, L
Format: Article
Language:English
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Summary:Background: Helicobacter pylori infection contributes to hypergastrinemia and hypersecretion of acid by blocking inhibitory reflex pathways to gastrin and parietal cells normally activated by antral distention. Our aim was to investigate whether a similar blockade of inhibitory responses could be provoked by inducing gastritis with aspirin, thus implicating a common inflammatory component, possibly a proinflammatory cytokine(s). Methods: We studied the effects of antral distention on stimulated acid secretion and gastrin release in H. pylori
ISSN:0036-5521
1502-7708
DOI:10.1080/00365529850170964