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Aspirin-induced Gastritis, Like Helicobacter pylori-induced Gastritis, Disinhibits Acid Secretion in Humans: Relation to Cytokine Expression
Background: Helicobacter pylori infection contributes to hypergastrinemia and hypersecretion of acid by blocking inhibitory reflex pathways to gastrin and parietal cells normally activated by antral distention. Our aim was to investigate whether a similar blockade of inhibitory responses could be pr...
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Published in: | Scandinavian journal of gastroenterology 1998, Vol.33 (4), p.346-356 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background: Helicobacter pylori infection contributes to hypergastrinemia and hypersecretion of acid by blocking inhibitory reflex pathways to gastrin and parietal cells normally activated by antral distention. Our aim was to investigate whether a similar blockade of inhibitory responses could be provoked by inducing gastritis with aspirin, thus implicating a common inflammatory component, possibly a proinflammatory cytokine(s). Methods: We studied the effects of antral distention on stimulated acid secretion and gastrin release in H. pylori |
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ISSN: | 0036-5521 1502-7708 |
DOI: | 10.1080/00365529850170964 |