Insecticidal and antifungal activities of aminorhodanine derivatives

Aminorhodanine (1) showed strong insecticidal activity against Culex pipiens pallens and Musca domestica, with respective LD50 values of 0.21 mu-g/insect and 0.87 mu-g/insect. Compound 1 had antifungal activity against Aspergillus niger ATCC-16404, Trichophyton mentagrophytes IFO-32412, Candida albi...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1998-05, Vol.62 (5), p.1025-1027
Main Authors: Inamori, Y. (os), Okamoto, Y, Takegawa, Y, Tsujibo, H, Sakagami, Y, Kumeda, Y, Shibata, M, Numata, A
Format: Article
Language:English
Subjects:
AMINO COMPOUNDS
aminorhodanine
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
antifungal activity
Antifungal agents
Antifungal Agents - pharmacology
ANTIFUNGAL PROPERTIES
ASPERGILLUS NIGER
BIOCHEMISTRY
BIOCHIMIE
Biological and medical sciences
BIOQUIMICA
CHEMICALS
COMPOSE AMINE
COMPUESTOS DE AMINA
Culex - drug effects
CULEX PIPIENS
Fundamental and applied biological sciences. Psychology
Fungi - drug effects
Houseflies - drug effects
insecticidal activity
INSECTICIDAS
INSECTICIDE
INSECTICIDES
Insecticides - pharmacology
Medical sciences
Medically important nuisances and vectors, pests of stored products and materials: population survey and control
Microbial Sensitivity Tests
MUSCA DOMESTICA
Nuisances
pathogenic fungus
Pharmacology. Drug treatments
PRODUCTOS QUIMICOS
PRODUIT CHIMIQUE
PROPIEDADES ANTIMICOSICAS
PROPRIETE ANTIFONGIQUE
rhodanine
Rhodanine - analogs & derivatives
Rhodanine - pharmacology
TRICHOPHYTON
Vectors. Intermediate hosts
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Description
Summary:Aminorhodanine (1) showed strong insecticidal activity against Culex pipiens pallens and Musca domestica, with respective LD50 values of 0.21 mu-g/insect and 0.87 mu-g/insect. Compound 1 had antifungal activity against Aspergillus niger ATCC-16404, Trichophyton mentagrophytes IFO-32412, Candida albicans ATCC-10231, Hansenula anomala OPS-308 and Penicillium expansum IFO-8800. In particular, 1 had potent antifungal activity against Aspergillus niger ATCC-16404, its minimal inhibitory concentration (MIC) being 6.25 mu-g/ml. Both activities of 1 were much higher than those of rhodanine (4), suggesting that the introduction of an amino group into N-3 of 4 plays an important role in the biological activity of rhodanine-related compounds. On the other hand, N-acetylaminorhodanine (2) and N-benzoylaminorhodanine (3) did not show either activity, suggesting that the free amino group at N-3 of 1 is closely related to the inhibitory activity of rhodanine derivatives
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.62.1025