Idiopathic CD4 + T-lymphocytopenia in a child with disseminated cryptococcosis

We describe a Malay girl with disseminated cryptococcosis affecting the lungs, liver, lymph nodes and bones. The diagnosis was made by culture of the bone marrow. Tests of immune function showed that she was HIV-negative but the CD4 percentage was persistently low. Idiopathic CD4 + T-lymphocytopenia...

Full description

Saved in:
Bibliographic Details
Published in:Annals of tropical paediatrics 1998-03, Vol.18 (1), p.45-48
Main Authors: Menon, Bina S., Shuaib, Ibrahim L., Zamari, Meor, Haq, J. Ashraful, Aiyar, Subramania, Noh, Lokman M.
Format: Article
Language:English
Subjects:
AIDS/HIV
Amphotericin B - therapeutic use
Antifungal Agents - therapeutic use
Antigens, Fungal - blood
Biological and medical sciences
Bone Marrow - microbiology
CD4 antigen
Child, Preschool
Cryptococcosis - complications
Cryptococcosis - drug therapy
Cryptococcosis - immunology
Cryptococcus
Drug Therapy, Combination
Fatal Outcome
Female
Fluconazole - therapeutic use
Flucytosine - therapeutic use
Human mycoses
Humans
Infectious diseases
Liver - microbiology
Lung - microbiology
Lymph Nodes - microbiology
lymphocytopenia
Malaysia
Medical sciences
Mycoses
Mycoses of the nervous system
T-Lymphocytopenia, Idiopathic CD4-Positive - complications
T-Lymphocytopenia, Idiopathic CD4-Positive - immunology
Tropical medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We describe a Malay girl with disseminated cryptococcosis affecting the lungs, liver, lymph nodes and bones. The diagnosis was made by culture of the bone marrow. Tests of immune function showed that she was HIV-negative but the CD4 percentage was persistently low. Idiopathic CD4 + T-lymphocytopenia was diagnosed. The child died despite two courses of anti-fungal therapy.
ISSN:0272-4936
2046-9047
1465-3281
2046-9055
DOI:10.1080/02724936.1998.11747925