Two-dimensional 220 MHz Fourier transform EPR imaging

In the last decade radiofrequency continuous-wave EPR spectrometers have been developed to detect and localize free radicals in vivo. Only recently, pulsed radiofrequency EPR spectrometers have been described for imaging applications with small samples. In the present work, we show the first two-dim...

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Bibliographic Details
Published in:Physics in medicine & biology 1998-07, Vol.43 (7), p.1845-1850
Main Authors: Placidi, Giuseppe, Brivati, John A, Alecci, Marcello, Testa, Luca, Sotgiu, Antonello
Format: Article
Language:English
Subjects:
Animals
Biophysical Phenomena
Biophysics
Electron Spin Resonance Spectroscopy - methods
Electron Spin Resonance Spectroscopy - statistics & numerical data
Fourier Analysis
Image Processing, Computer-Assisted
Phantoms, Imaging
Radio Waves
Rats
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Summary:In the last decade radiofrequency continuous-wave EPR spectrometers have been developed to detect and localize free radicals in vivo. Only recently, pulsed radiofrequency EPR spectrometers have been described for imaging applications with small samples. In the present work, we show the first two-dimensional image obtained at 220 MHz on a large phantom (40 ml) that simulates typical conditions of in vivo EPR imaging. This pulsed EPR apparatus has the potential to make the time required for three-dimensional imaging compatible with the biological half-life of normally used paramagnetic probes.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/43/7/004