Vancomycin and cardiac arrest in the infant

Different adverse effects induced by vancomycin bolus infusion are described, but cardiac arrest seems rare, in children as in adults. Two infants, 5 and 12 months old, were admitted after cardiac arrest, following vancomycin bolus infusion in excessive dose. They recovered after prompt resuscitatio...

Full description

Saved in:
Bibliographic Details
Published in:Archives de pédiatrie : organe officiel de la Société française de pédiatrie 1998-05, Vol.5 (5), p.521
Main Authors: Trentesaux, A S, Bednarek, N, Morville, P
Format: Article
Language:fre
Subjects:
Anaphylaxis - chemically induced
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Female
Heart Arrest - chemically induced
Humans
Infant
Infusions, Intravenous
Male
Vancomycin - administration & dosage
Vancomycin - adverse effects
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Different adverse effects induced by vancomycin bolus infusion are described, but cardiac arrest seems rare, in children as in adults. Two infants, 5 and 12 months old, were admitted after cardiac arrest, following vancomycin bolus infusion in excessive dose. They recovered after prompt resuscitation and their short term follow-up was normal. Two mechanisms are invoked: anaphylactic shock and direct cardiovascular toxicity. Both are dose- and infusion rate-dependent, and probably intersubject dependent. Usually, cardiac arrest is promptly reversed by adequate resuscitation. The rules of prescription are: adequate dilution and slow rate of infusion. If any adverse effect occurred, preventive antihistaminic drug therapy should be advised.
ISSN:0929-693X
DOI:10.1016/S0929-693X(99)80318-2