Vancomycin and cardiac arrest in the infant

Different adverse effects induced by vancomycin bolus infusion are described, but cardiac arrest seems rare, in children as in adults. Two infants, 5 and 12 months old, were admitted after cardiac arrest, following vancomycin bolus infusion in excessive dose. They recovered after prompt resuscitatio...

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Published in:Archives de pédiatrie : organe officiel de la Société française de pédiatrie 1998-05, Vol.5 (5), p.521
Main Authors: Trentesaux, A S, Bednarek, N, Morville, P
Format: Article
Language:fre
Subjects:
Anaphylaxis - chemically induced
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Female
Heart Arrest - chemically induced
Humans
Infant
Infusions, Intravenous
Male
Vancomycin - administration & dosage
Vancomycin - adverse effects
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creator Trentesaux, A S
Bednarek, N
Morville, P
description Different adverse effects induced by vancomycin bolus infusion are described, but cardiac arrest seems rare, in children as in adults. Two infants, 5 and 12 months old, were admitted after cardiac arrest, following vancomycin bolus infusion in excessive dose. They recovered after prompt resuscitation and their short term follow-up was normal. Two mechanisms are invoked: anaphylactic shock and direct cardiovascular toxicity. Both are dose- and infusion rate-dependent, and probably intersubject dependent. Usually, cardiac arrest is promptly reversed by adequate resuscitation. The rules of prescription are: adequate dilution and slow rate of infusion. If any adverse effect occurred, preventive antihistaminic drug therapy should be advised.
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ispartof Archives de pédiatrie : organe officiel de la Société française de pédiatrie, 1998-05, Vol.5 (5), p.521
issn 0929-693X
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source Elsevier
subjects Anaphylaxis - chemically induced
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Female
Heart Arrest - chemically induced
Humans
Infant
Infusions, Intravenous
Male
Vancomycin - administration & dosage
Vancomycin - adverse effects
title Vancomycin and cardiac arrest in the infant
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