Intralipid Enhances alpha1-Adrenergic Receptor-Mediated Pressor Sensitivity

The dyslipidemia in obese hypertensive persons may contribute to their increased vascular alpha-adrenergic receptor reactivity and tone. To further examine this notion, we conducted 2 studies of pressor sensitivity to phenylephrine, an alpha1-adrenergic receptor agonist, in lean normotensive subject...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1998-10, Vol.32 (4), p.693-698
Main Authors: Haastrup, Adetola T, Stepniakowski, Konrad T, Goodfriend, Theodore L, Egan, Brent M
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - pharmacology
Adult
Anticoagulants - pharmacology
Blood Pressure - drug effects
Dose-Response Relationship, Drug
Drug Interactions
Fat Emulsions, Intravenous - pharmacology
Fatty Acids, Nonesterified - blood
Female
Heparin - pharmacology
Humans
Male
Phenylephrine - pharmacology
Pressoreceptors - drug effects
Receptors, Adrenergic, alpha - drug effects
Triglycerides - blood
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Summary:The dyslipidemia in obese hypertensive persons may contribute to their increased vascular alpha-adrenergic receptor reactivity and tone. To further examine this notion, we conducted 2 studies of pressor sensitivity to phenylephrine, an alpha1-adrenergic receptor agonist, in lean normotensive subjects. In the first study (n=6), pressor responses to phenylephrine were obtained before and during a saline and heparin infusion. On another day, pressor reactivity to phenylephrine was measured before and during infusion of 20% Intralipid at 0.5 mL [middle dot] m [middle dot] min with heparin at 1000 U/h to increase lipoprotein lipase activity and raise nonesterified fatty acids (NEFAs). In the second study (n=8), baseline reactivity to phenylephrine was obtained on 2 separate days and repeated after raising NEFAs and triglycerides either with 0.8 mL [middle dot] m [middle dot] min of 20% Intralipid alone or together with heparin. The infusion of saline and heparin did not significantly change plasma NEFAs from baseline (516 +/- 90 versus 512 +/- 108 [micro sign]mol/L, respectively; P=NS) or the dose of phenylephrine required to raise mean blood pressure by 20 mm Hg ([PD20PE]; 1.00 +/- 0.14 versus 0.95 +/- 0.10 [micro sign]g [middle dot] kg [middle dot] min, respectively, P=NS). Intralipid at 0.5 mL [middle dot] m [middle dot] min with heparin raised plasma NEFAs to 793 +/- 30 [micro sign]mol/L per liter (P
ISSN:0194-911X
1524-4563