In vivo modulation of iododeoxyuridine metabolism and incorporation into cellular DNA by 5'-amino-5'-deoxythymidine in normal mouse tissues and two human colon cancer xenografts

This in vivo study examines the ability of 5'-amino-5'-deoxythymidine (5'-AdThd) to modulate 5-iododeoxyuridine (IdUrd) cellular metabolism in two human colon cancer xenografts (HT 29 and HCT-116), two actively proliferating normal mouse tissues (bone marrow and intestine), and a quie...

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Bibliographic Details
Published in:Clinical cancer research 1996-06, Vol.2 (6), p.981-989
Main Authors: KINSELLA, T. J, GLENNON, M. C, KUNUGI, K. A, LINDSTROM, M. J
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Chemotherapy
Colonic Neoplasms - metabolism
Dideoxynucleosides - pharmacology
Dideoxynucleosides - toxicity
DNA - metabolism
Dose-Response Relationship, Drug
Female
HT29 Cells
Humans
Idoxuridine - metabolism
Idoxuridine - toxicity
Medical sciences
Mice
Mice, Nude
Neoplasm Transplantation
Pharmacology. Drug treatments
Transplantation, Heterologous
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Summary:This in vivo study examines the ability of 5'-amino-5'-deoxythymidine (5'-AdThd) to modulate 5-iododeoxyuridine (IdUrd) cellular metabolism in two human colon cancer xenografts (HT 29 and HCT-116), two actively proliferating normal mouse tissues (bone marrow and intestine), and a quiescent normal mouse tissue (liver). 5'-AdThd is a thymidine analogue that at low concentrations (
ISSN:1078-0432
1557-3265