New growth hormone secretagogues: from physiology to the first therapeutic applications

Growth hormone releasing peptides (GHRP) are synthetic hexapeptides that physiologically stimulate GH release through two different pathways: 1) central and 2) direct action on somatotropic cells. Animal experiments and first clinical trials show that synthetic GHRP and synthetic analogues could be...

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Bibliographic Details
Published in:Archives de pédiatrie : organe officiel de la Société française de pédiatrie 1998, Vol.5 Suppl 4, p.390S
Main Authors: Ahnfelt-Rønne, I, Haahr, P M
Format: Article
Language:fre
Subjects:
Animals
Clinical Trials as Topic
Disease Models, Animal
Drug Evaluation, Preclinical
Growth Disorders - drug therapy
Growth Disorders - etiology
Growth Hormone - deficiency
Growth Hormone - metabolism
Growth Hormone - therapeutic use
Humans
Oligopeptides - physiology
Oligopeptides - therapeutic use
Pituitary Gland - drug effects
Rats
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Summary:Growth hormone releasing peptides (GHRP) are synthetic hexapeptides that physiologically stimulate GH release through two different pathways: 1) central and 2) direct action on somatotropic cells. Animal experiments and first clinical trials show that synthetic GHRP and synthetic analogues could be useful substitutes to recombinant GH in the treatment of GH deficiency, and in pathological conditions which may benefit from amplification of the GH-IGF I axis activity.
ISSN:0929-693X