The Implications of Hyperhomocysteinemia in a Patient with Type 1 Diabetes

We present a patient with type 1 diabetes mellitus, who had severe, progressive macrovascular disease despite an optimal control of modifiable risk factors. Screening for other risk factors revealed a markedly elevated plasma homocysteine level, that was secondary to pernicious anemia. The biologica...

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Bibliographic Details
Published in:Acta clinica belgica (English ed. Online) 1998-10, Vol.53 (5), p.349-352
Main Authors: van Leeuwen-Wintjeris, H.R.A.J.B., Muls, E.E.
Format: Article
Language:English
Subjects:
Anemia, Pernicious - complications
Arteriosclerosis - etiology
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - prevention & control
Gastritis, Atrophic - etiology
Humans
Hyperhomocysteinemia - complications
Male
Middle Aged
Risk Factors
Vitamin B Deficiency - etiology
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Summary:We present a patient with type 1 diabetes mellitus, who had severe, progressive macrovascular disease despite an optimal control of modifiable risk factors. Screening for other risk factors revealed a markedly elevated plasma homocysteine level, that was secondary to pernicious anemia. The biological and clinical implications of this association are discussed.
ISSN:1784-3286
2295-3337
DOI:10.1080/17843286.1998.11754188