Microcapsule agglutination test for the diagnosis of leptospirosis in Thailand

Sera from 82 cases of leptospirosis (confirmed by micro-agglutination tests or IFAT) and 108 patients with other diseases were investigated using the microcapsule agglutination test (MCAT) for leptospirosis. The overall sensitivity (90.2%), specificity (96.3%), positive predictive value (94.9%), neg...

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Bibliographic Details
Published in:Annals of tropical medicine and parasitology 1998-10, Vol.92 (7), p.797-801
Main Authors: Suputtamongkol, Y., Sarawish, S., Silpasakorn, S., Potha, U., Silpapojakul, K., Naigowit, P.
Format: Article
Language:English
Subjects:
Agglutination Tests - methods
Bacterial diseases
Biological and medical sciences
Fever - etiology
Fluorescent Antibody Technique, Indirect
Human bacterial diseases
Humans
Infectious diseases
Leptospira interrogans - isolation & purification
Leptospirosis - complications
Leptospirosis - diagnosis
Medical sciences
Miscellaneous
Sensitivity and Specificity
Thailand
Tropical bacterial diseases
Tropical medicine
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Summary:Sera from 82 cases of leptospirosis (confirmed by micro-agglutination tests or IFAT) and 108 patients with other diseases were investigated using the microcapsule agglutination test (MCAT) for leptospirosis. The overall sensitivity (90.2%), specificity (96.3%), positive predictive value (94.9%), negative predictive value (92.9%), and accuracy of the MCAT (93.7%) were encouraging. MCAT is simple, can be performed by unskilled personnel with minimum laboratory facilities, and produces results in 3 h. MCAT would be a reliable serodiagnostic test for rapidly screening individuals for leptospirosis, in various geographical areas of Thailand.
ISSN:0003-4983
1364-8594
DOI:10.1080/00034983.1998.11813342