TARGETING AND ASSEMBLY OF PERIPLASMIC AND OUTER-MEMBRANE PROTEINS IN ESCHERICHIA COLI

Escherichia coli must actively transport many of its proteins to extracytoplasmic compartments such as the periplasm and outer membrane. To perform this duty, E. coli employs a collection of Sec (secretion) proteins that catalyze the translocation of various polypeptides through the inner membrane....

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Bibliographic Details
Published in:Annual review of genetics 1998-01, Vol.32 (1), p.59-94
Main Authors: Danese, Paul N, Silhavy, Thomas J
Format: Article
Language:English
Subjects:
Bacteria
Bacterial Outer Membrane Proteins - chemistry
Bacterial Outer Membrane Proteins - metabolism
Bacterial Proteins - chemistry
Bacterial Proteins - metabolism
Bacteriology
Biological and medical sciences
Biological Transport, Active
Cell Membrane - metabolism
Cellular biology
Cpx
Cytoplasm - metabolism
E coli
Escherichia coli
Escherichia coli - metabolism
Fundamental and applied biological sciences. Psychology
Genetic aspects
Genetics
Membrane proteins
Membranes
Microbiology
Models, Biological
Polypeptides
Protein Folding
protein translocation
Proteins
SecY
sigma-E
Signal Transduction
stress response
Translocation
Translocations (Genetics)
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Summary:Escherichia coli must actively transport many of its proteins to extracytoplasmic compartments such as the periplasm and outer membrane. To perform this duty, E. coli employs a collection of Sec (secretion) proteins that catalyze the translocation of various polypeptides through the inner membrane. After translocation across the inner membrane, periplasmic and outer-membrane proteins are folded and targeted to their appropriate destinations. Here we review our knowledge of protein translocation across the inner membrane. We also discuss the various signal transduction systems that monitor extracytoplasmic protein folding and targeting, and we consider how these signal transduction systems may ultimately control these processes.
ISSN:0066-4197
1545-2948
DOI:10.1146/annurev.genet.32.1.59