Toxicity studies in mice of common spices, Cinnamomum zeylanicum bark and Piper longum fruits

Acute (24 hours) and chronic (90 days) oral toxicity studies on the ethanolic extracts of common spices Cinnamomum zeylanicum Nees bark and Piper longum L. fruits were carried out in mice. Acute dosages were 0.5, 1.0 and 3 g/kg while the chronic dosage was 100 mg/kg/day. All external morphological,...

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Bibliographic Details
Published in:Plant foods for human nutrition (Dordrecht) 1998, Vol.52 (3), p.231-239
Main Authors: Shah, A.H. (Central Lab. for Drug and Food Analysis, Riyadh (Saudi Arabia).), Al-Shareef, A.H, Ageel, A.M, Qureshi, S
Format: Article
Language:English
Subjects:
Animals
BARK
Biological and medical sciences
CINNAMOMUM ZEYLANICUM
CORTEZA
Drug toxicity and drugs side effects treatment
ECORCE
Female
FRUIT
FRUTO
Hemoglobins - metabolism
Liver - anatomy & histology
Lung - anatomy & histology
Male
Medical sciences
MICE
Miscellaneous (drug allergy, mutagens, teratogens...)
Organ Size
Pharmacology. Drug treatments
PIPER LONGUM
Plant poisons toxicology
RATON
SOURIS
Sperm Count
Sperm Motility
Spices - toxicity
Spleen - anatomy & histology
TOXICIDAD
TOXICITE
TOXICITY
Toxicology
Weight Gain
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Summary:Acute (24 hours) and chronic (90 days) oral toxicity studies on the ethanolic extracts of common spices Cinnamomum zeylanicum Nees bark and Piper longum L. fruits were carried out in mice. Acute dosages were 0.5, 1.0 and 3 g/kg while the chronic dosage was 100 mg/kg/day. All external morphological, hematological and spermatogenic changes, in addition to body weight and vital organ weights, were recorded. The extracts of both the plants caused no significant acute or chronic mortality compared to the control during this study. During chronic treatment there was no significant change in the pre- and post treatment body weight of the test animals while the weight gain in the control group was significant. C. zeylanicum treatment caused reduction in liver weight while P. longum caused a significant increase in the weight of the lungs and spleen of the treated animals compared to the control. Hematological studies revealed a significant fall in hemoglobin level of C. zeylanicum treated animals. Both of the extracts induced a significant increase in reproductive organ weights, sperm motility, sperm count and failed to illicit any spermatotoxic effect.
ISSN:0921-9668
1573-9104
DOI:10.1023/A:1008088323164