Liquid Biopsies, Novel Approaches and Future Directions

Cancer is among the leading causes of death worldwide. Early diagnosis and prognosis are vital to improve patients' outcomes. The gold standard of tumor characterization leading to tumor diagnosis and prognosis is tissue biopsy. Amongst the constraints of tissue biopsy collection is the samplin...

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Bibliographic Details
Published in:Cancers 2023-03, Vol.15 (5), p.1579
Main Authors: Armakolas, Athanasios, Kotsari, Maria, Koskinas, John
Format: Article
Language:English
Subjects:
Antigens
Biopsy
Blood
Body fluids
Bone marrow
Breast cancer
Cancer
Cell adhesion & migration
Diagnosis
Disease management
Forecasts and trends
Health aspects
Innovations
Invasiveness
Metastases
Metastasis
Methods
Patients
Prognosis
Prostate
Review
Stem cells
Tumor cells
Tumors
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Summary:Cancer is among the leading causes of death worldwide. Early diagnosis and prognosis are vital to improve patients' outcomes. The gold standard of tumor characterization leading to tumor diagnosis and prognosis is tissue biopsy. Amongst the constraints of tissue biopsy collection is the sampling frequency and the incomplete representation of the entire tumor bulk. Liquid biopsy approaches, including the analysis of circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), circulating miRNAs, and tumor-derived extracellular vesicles (EVs), as well as certain protein signatures that are released in the circulation from primary tumors and their metastatic sites, present a promising and more potent candidate for patient diagnosis and follow up monitoring. The minimally invasive nature of liquid biopsies, allowing frequent collection, can be used in the monitoring of therapy response in real time, allowing the development of novel approaches in the therapeutic management of cancer patients. In this review we will describe recent advances in the field of liquid biopsy markers focusing on their advantages and disadvantages.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15051579