The Influence of Ethnicity on Survival from Malignant Primary Brain Tumours in England: A Population-Based Cohort Study

• Published in: Cancers 2023-02, Vol.15 (5), p.1464
• Main Authors: Wanis, Hiba A, Møller, Henrik, Ashkan, Keyoumars, Davies, Elizabeth A
• Format: Article
• Language: English
• Subjects: Age; Brain cancer; Brain research; Brain tumors; Cancer therapies; Care and treatment; Chemotherapy; Classification; Cohort analysis; Diagnosis; Ethnicity; Fatalities; Glioblastoma; Hospitals; Influence; Lymphoma; Medical diagnosis; Minority & ethnic groups; Morbidity; Morphology; Nervous system; Patient outcomes; Patients; Population; Population studies; Population-based studies; Precision medicine; Radiation therapy; Registration; Survival; Tumors
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers15051464

In recent years, the completeness of ethnicity data in the English cancer registration data has greatly improved. Using these data, this study aims to estimate the influence of ethnicity on survival from primary malignant brain tumours. Demographic and clinical data on adult patients diagnosed with malignant primary brain tumour from 2012 to 2017 were obtained ( = 24,319). Univariate and multivariate Cox proportional hazards regression analyses were used to estimate hazard ratios (HR) for the survival of the ethnic groups up to one year following diagnosis. Logistic regressions were then used to estimate odds ratios (OR) for different ethnic groups of (1) being diagnosed with pathologically confirmed glioblastoma, (2) being diagnosed through a hospital stay that included an emergency admission, and (3) receiving optimal treatment. After an adjustment for known prognostic factors and factors potentially affecting access to healthcare, patients with an Indian background (HR 0.84, 95% CI 0.72-0.98), Any Other White (HR 0.83, 95% CI 0.76-0.91), Other Ethnic Group (HR 0.70, 95% CI 0.62-0.79), and Unknown/Not Stated Ethnicity (HR 0.81, 95% CI 0.75-0.88) had better one-year survivals than the White British Group. Individuals with Unknown ethnicity are less likely be diagnosed with glioblastoma (OR 0.70, 95% CI 0.58-0.84) and less likely to be diagnosed through a hospital stay that included an emergency admission (OR 0.61, 95% CI 0.53-0.69). The demonstrated ethnic variations associated with better brain tumour survival suggests the need to identify risk or protective factors that may underlie these differences in patient outcomes.