Association between Age at Helicobacter pylori Eradication and the Risk of Gastric Cancer Stratified by Family History of Gastric Cancer: A Nationwide Population-Based Study

This study compares the risk of GC according to age at eradication, stratified based on the presence of family history of GC using a population-based large cohort. We analyzed individuals who underwent GC screening between 2013 and 2014 and received eradication therapy before screening. Among 1,888,...

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Published in:Cancers 2023-03, Vol.15 (5), p.1604
Main Authors: Jung, Yoon Suk, Tran, Mai Thi Xuan, Song, Huiyeon, Park, Boyoung, Moon, Chang Mo
Format: Article
Language:English
Subjects:
Age
Body mass index
Codes
Comorbidity
Disease
Eradication
Family medical history
Gastric cancer
Gastrointestinal surgery
Medical research
Medical screening
Population studies
Population-based studies
Questionnaires
Tumors
Ulcers
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container_issue 5
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container_title Cancers
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creator Jung, Yoon Suk
Tran, Mai Thi Xuan
Song, Huiyeon
Park, Boyoung
Moon, Chang Mo
description This study compares the risk of GC according to age at eradication, stratified based on the presence of family history of GC using a population-based large cohort. We analyzed individuals who underwent GC screening between 2013 and 2014 and received eradication therapy before screening. Among 1,888,815 -treated patients, 2610/294,706 and 9332/1,594,109 patients with and without a family history of GC, respectively, developed GC. After adjusting for confounders, including age at screening, the adjusted hazard ratios (95% confidence intervals) for GC comparison, 70-74, 65-69, 60-64, 55-59, 50-54, 45-49, and
doi_str_mv 10.3390/cancers15051604
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We analyzed individuals who underwent GC screening between 2013 and 2014 and received eradication therapy before screening. Among 1,888,815 -treated patients, 2610/294,706 and 9332/1,594,109 patients with and without a family history of GC, respectively, developed GC. After adjusting for confounders, including age at screening, the adjusted hazard ratios (95% confidence intervals) for GC comparison, 70-74, 65-69, 60-64, 55-59, 50-54, 45-49, and &lt;45 years with ≥75 years at eradication were 0.98 (0.79-1.21), 0.88 (0.74-1.05), 0.76 (0.59-0.99), 0.62 (0.44-0.88), 0.57 (0.36-0.90), 0.38 (0.22-0.66), and 0.34 (0.17-0.67), respectively, among patients with a family history of GC ( &lt; 0.001) and 1.01 (0.91-1.13), 0.95 (0.86-1.04), 0.86 (0.75-0.98), 0.67 (0.56-0.81), 0.56 (0.44-0.71), 0.51 (0.38-0.68), and 0.33 (0.23-0.47), respectively, among patients without a family history of GC ( &lt; 0.001). In patients with and without a family history of GC, young age at eradication was significantly associated with a reduced risk of GC, suggesting that the early treatment of infection can maximize GC prevention.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15051604</identifier><identifier>PMID: 36900395</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Body mass index ; Codes ; Comorbidity ; Disease ; Eradication ; Family medical history ; Gastric cancer ; Gastrointestinal surgery ; Medical research ; Medical screening ; Population studies ; Population-based studies ; Questionnaires ; Tumors ; Ulcers</subject><ispartof>Cancers, 2023-03, Vol.15 (5), p.1604</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. 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We analyzed individuals who underwent GC screening between 2013 and 2014 and received eradication therapy before screening. Among 1,888,815 -treated patients, 2610/294,706 and 9332/1,594,109 patients with and without a family history of GC, respectively, developed GC. After adjusting for confounders, including age at screening, the adjusted hazard ratios (95% confidence intervals) for GC comparison, 70-74, 65-69, 60-64, 55-59, 50-54, 45-49, and &lt;45 years with ≥75 years at eradication were 0.98 (0.79-1.21), 0.88 (0.74-1.05), 0.76 (0.59-0.99), 0.62 (0.44-0.88), 0.57 (0.36-0.90), 0.38 (0.22-0.66), and 0.34 (0.17-0.67), respectively, among patients with a family history of GC ( &lt; 0.001) and 1.01 (0.91-1.13), 0.95 (0.86-1.04), 0.86 (0.75-0.98), 0.67 (0.56-0.81), 0.56 (0.44-0.71), 0.51 (0.38-0.68), and 0.33 (0.23-0.47), respectively, among patients without a family history of GC ( &lt; 0.001). 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subjects Age
Body mass index
Codes
Comorbidity
Disease
Eradication
Family medical history
Gastric cancer
Gastrointestinal surgery
Medical research
Medical screening
Population studies
Population-based studies
Questionnaires
Tumors
Ulcers
title Association between Age at Helicobacter pylori Eradication and the Risk of Gastric Cancer Stratified by Family History of Gastric Cancer: A Nationwide Population-Based Study
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