Cobalamin (Vitamin B12) in Anticancer Photodynamic Therapy with Zn(II) Phthalocyanines

Photodynamic therapy (PDT) is a curative method, firstly developed for cancer therapy with fast response after treatment and minimum side effects. Two zinc(II) phthalocyanines (3ZnPc and 4ZnPc) and a hydroxycobalamin (Cbl) were investigated on two breast cancer cell lines (MDA-MB-231 and MCF-7) in c...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2023-02, Vol.24 (5), p.4400
Main Authors: Mantareva, Vanya, Iliev, Ivan, Sulikovska, Inna, Durmuş, Mahmut, Angelov, Ivan
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Cancer therapies
Cell Line, Tumor
Cells
Cytotoxicity
Humans
Hydroxycobalamin
Isoindoles
MCF-7 Cells
Organometallic Compounds - pharmacology
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - pharmacology
Phototoxicity
Selectivity
Toxicity
Tumor cell lines
Vitamin B 12
Vitamin B12
Zinc
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Photodynamic therapy (PDT) is a curative method, firstly developed for cancer therapy with fast response after treatment and minimum side effects. Two zinc(II) phthalocyanines (3ZnPc and 4ZnPc) and a hydroxycobalamin (Cbl) were investigated on two breast cancer cell lines (MDA-MB-231 and MCF-7) in comparison to normal cell lines (MCF-10 and BALB 3T3). The novelty of this study is a complex of non-peripherally methylpyridiloxy substituted Zn(II) phthalocyanine (3ZnPc) and the evaluation of the effects on different cell lines due to the addition of second porphyrinoid such as Cbl. The results showed the complete photocytotoxicity of both ZnPc-complexes at lower concentrations (
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24054400