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Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study
The aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and to evaluate their potential impact on ICSI outcomes. It is a prospective case-control study conducted on 25 women with proven endometriosis and 50 patients diagnosed with other ca...
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| Published in: | Journal of clinical medicine 2023-02, Vol.12 (5), p.1829 |
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| container_issue | 5 |
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| container_title | Journal of clinical medicine |
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| creator | Kacem-Berjeb, Khadija Braham, Marouen Massoud, Cyrine Ben Hannachi, Hela Hamdoun, Manel Chtourou, Sana Debbabi, Linda Bouyahia, Maha Fadhlaoui, Anis Zhioua, Fethi Feki, Anis Chakroun, Nozha Bahri, Olfa |
| description | The aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and to evaluate their potential impact on ICSI outcomes.
It is a prospective case-control study conducted on 25 women with proven endometriosis and 50 patients diagnosed with other causes of infertility. All these patients were candidates for ICSI cycles. Their follicular fluid was collected at the time of oocyte retrieval and used to evaluate IL-6 and AMH titers by electro-chemiluminescent immunoassay (Cobas e411-Roche).
The IL-6 levels in follicular fluid were higher in the endometriosis group than in the control group (152.3 vs. 19.9 pg/mL;
= 0.02). The median level for AMH was 2.2 ± 1.88 ng/mL with no statistical difference between the two groups (2.2 vs. 2.7 ng/mL,
= 0.41). No significant correlation between the follicular IL6 and AMH levels was observed.
The oocyte quality seems to be preserved in patients with endometriosis with the adequate response to ovarian stimulation. High levels of follicular IL6 are in accordance with the inflammatory phenomenon of the disease; however, this increase has no impact on ICSI outcomes. |
| doi_str_mv | 10.3390/jcm12051829 |
| format | article |
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It is a prospective case-control study conducted on 25 women with proven endometriosis and 50 patients diagnosed with other causes of infertility. All these patients were candidates for ICSI cycles. Their follicular fluid was collected at the time of oocyte retrieval and used to evaluate IL-6 and AMH titers by electro-chemiluminescent immunoassay (Cobas e411-Roche).
The IL-6 levels in follicular fluid were higher in the endometriosis group than in the control group (152.3 vs. 19.9 pg/mL;
= 0.02). The median level for AMH was 2.2 ± 1.88 ng/mL with no statistical difference between the two groups (2.2 vs. 2.7 ng/mL,
= 0.41). No significant correlation between the follicular IL6 and AMH levels was observed.
The oocyte quality seems to be preserved in patients with endometriosis with the adequate response to ovarian stimulation. High levels of follicular IL6 are in accordance with the inflammatory phenomenon of the disease; however, this increase has no impact on ICSI outcomes.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12051829</identifier><identifier>PMID: 36902616</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Analysis ; Anti-Müllerian hormone ; Care and treatment ; Clinical medicine ; Cytokines ; Diagnosis ; Embryos ; Endometriosis ; Fertility ; Infertility ; Interleukin-6 ; Ovaries ; Statistical analysis ; Ultrasonic imaging ; Womens health</subject><ispartof>Journal of clinical medicine, 2023-02, Vol.12 (5), p.1829</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c435t-2ecee9fc5ff9cc87fb650913582b634a4bfba3b29ffc7cbf5e26f96d0e6026423</cites><orcidid>0000-0002-3324-9529 ; 0000-0002-8861-3471 ; 0000-0002-9817-9445 ; 0000-0001-7572-2495</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2785208357/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2785208357?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36902616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kacem-Berjeb, Khadija</creatorcontrib><creatorcontrib>Braham, Marouen</creatorcontrib><creatorcontrib>Massoud, Cyrine Ben</creatorcontrib><creatorcontrib>Hannachi, Hela</creatorcontrib><creatorcontrib>Hamdoun, Manel</creatorcontrib><creatorcontrib>Chtourou, Sana</creatorcontrib><creatorcontrib>Debbabi, Linda</creatorcontrib><creatorcontrib>Bouyahia, Maha</creatorcontrib><creatorcontrib>Fadhlaoui, Anis</creatorcontrib><creatorcontrib>Zhioua, Fethi</creatorcontrib><creatorcontrib>Feki, Anis</creatorcontrib><creatorcontrib>Chakroun, Nozha</creatorcontrib><creatorcontrib>Bahri, Olfa</creatorcontrib><title>Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>The aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and to evaluate their potential impact on ICSI outcomes.
It is a prospective case-control study conducted on 25 women with proven endometriosis and 50 patients diagnosed with other causes of infertility. All these patients were candidates for ICSI cycles. Their follicular fluid was collected at the time of oocyte retrieval and used to evaluate IL-6 and AMH titers by electro-chemiluminescent immunoassay (Cobas e411-Roche).
The IL-6 levels in follicular fluid were higher in the endometriosis group than in the control group (152.3 vs. 19.9 pg/mL;
= 0.02). The median level for AMH was 2.2 ± 1.88 ng/mL with no statistical difference between the two groups (2.2 vs. 2.7 ng/mL,
= 0.41). No significant correlation between the follicular IL6 and AMH levels was observed.
The oocyte quality seems to be preserved in patients with endometriosis with the adequate response to ovarian stimulation. High levels of follicular IL6 are in accordance with the inflammatory phenomenon of the disease; however, this increase has no impact on ICSI outcomes.</description><subject>Age</subject><subject>Analysis</subject><subject>Anti-Müllerian hormone</subject><subject>Care and treatment</subject><subject>Clinical medicine</subject><subject>Cytokines</subject><subject>Diagnosis</subject><subject>Embryos</subject><subject>Endometriosis</subject><subject>Fertility</subject><subject>Infertility</subject><subject>Interleukin-6</subject><subject>Ovaries</subject><subject>Statistical analysis</subject><subject>Ultrasonic imaging</subject><subject>Womens health</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptks9rFDEUxwdRbKk9eZeAF0Gm5sckMzmVZezahRUP6jlkMi9tlkyyJjOF_vdmaa1bMTkkvHzeN-_7eFX1luALxiT-tDMToZiTjsoX1SnFbVtj1rGXR_eT6jznHS6r6xpK2tfVCRMSU0HEaTV8jpDRVRjjBHNyMbuMNtNemxnNt4D6OO1LbHYxoGjROnrvzOJ1Qmu_uBG5gDZbgXQY0err9SVaoV5nqPsY5hQ9-j4v4_2b6pXVPsP543lW_Vxf_eiv6-23L5t-ta1Nw_hcUzAA0hpurTSma-0gOJaE8Y4OgjW6Geyg2UCltaY1g-VAhZVixCCKl4ays-ryQXe_DBOMBkoN2qt9cpNO9ypqp56_BHerbuKdIqU1VGJSFD48KqT4a4E8q8llA97rAHHJiradwLJpOlbQ9_-gu7ikUPwdKE5xx3j7l7rRHpQLNpaPzUFUrVqOGeMNORR-8R-q7BEmZ2IA60r8WcLHhwSTYs4J7JNJgtVhLNTRWBT63XFfntg_Q8B-A5hwsK8</recordid><startdate>20230224</startdate><enddate>20230224</enddate><creator>Kacem-Berjeb, Khadija</creator><creator>Braham, Marouen</creator><creator>Massoud, Cyrine Ben</creator><creator>Hannachi, Hela</creator><creator>Hamdoun, Manel</creator><creator>Chtourou, Sana</creator><creator>Debbabi, Linda</creator><creator>Bouyahia, Maha</creator><creator>Fadhlaoui, Anis</creator><creator>Zhioua, Fethi</creator><creator>Feki, Anis</creator><creator>Chakroun, Nozha</creator><creator>Bahri, Olfa</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3324-9529</orcidid><orcidid>https://orcid.org/0000-0002-8861-3471</orcidid><orcidid>https://orcid.org/0000-0002-9817-9445</orcidid><orcidid>https://orcid.org/0000-0001-7572-2495</orcidid></search><sort><creationdate>20230224</creationdate><title>Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? 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A Case-Control Study</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2023-02-24</date><risdate>2023</risdate><volume>12</volume><issue>5</issue><spage>1829</spage><pages>1829-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>The aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and to evaluate their potential impact on ICSI outcomes.
It is a prospective case-control study conducted on 25 women with proven endometriosis and 50 patients diagnosed with other causes of infertility. All these patients were candidates for ICSI cycles. Their follicular fluid was collected at the time of oocyte retrieval and used to evaluate IL-6 and AMH titers by electro-chemiluminescent immunoassay (Cobas e411-Roche).
The IL-6 levels in follicular fluid were higher in the endometriosis group than in the control group (152.3 vs. 19.9 pg/mL;
= 0.02). The median level for AMH was 2.2 ± 1.88 ng/mL with no statistical difference between the two groups (2.2 vs. 2.7 ng/mL,
= 0.41). No significant correlation between the follicular IL6 and AMH levels was observed.
The oocyte quality seems to be preserved in patients with endometriosis with the adequate response to ovarian stimulation. High levels of follicular IL6 are in accordance with the inflammatory phenomenon of the disease; however, this increase has no impact on ICSI outcomes.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36902616</pmid><doi>10.3390/jcm12051829</doi><orcidid>https://orcid.org/0000-0002-3324-9529</orcidid><orcidid>https://orcid.org/0000-0002-8861-3471</orcidid><orcidid>https://orcid.org/0000-0002-9817-9445</orcidid><orcidid>https://orcid.org/0000-0001-7572-2495</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of clinical medicine, 2023-02, Vol.12 (5), p.1829 |
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| subjects | Age Analysis Anti-Müllerian hormone Care and treatment Clinical medicine Cytokines Diagnosis Embryos Endometriosis Fertility Infertility Interleukin-6 Ovaries Statistical analysis Ultrasonic imaging Womens health |
| title | Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study |
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