The Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease

The study of osteoblast (OB) metabolism has recently received increased attention due to the considerable amount of energy used during the bone remodeling process. In addition to glucose, the main nutrient for the osteoblast lineages, recent data highlight the importance of amino acid and fatty acid...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-03, Vol.24 (5), p.4893
Main Authors: Lungu, Oxana, Toscani, Denise, Burroughs-Garcia, Jessica, Giuliani, Nicola
Format: Article
Language:English
Subjects:
Amino acids
Apoptosis
Bone and Bones - metabolism
Bone diseases
Bone Diseases - metabolism
Bone marrow
Bone remodeling
Cell Differentiation - physiology
Differentiation
Fatty acids
Gene expression
Glucose
Glutamine
Growth factors
Humans
Kinases
Metabolic pathways
Metabolism
Multiple myeloma
Multiple Myeloma - pathology
Osteoblasts
Osteoblasts - metabolism
Phosphorylation
Physiological aspects
Physiology
Plasma cells
Proteins
Review
Signal transduction
Stem cells
Transcription factors
Tumor Microenvironment
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Summary:The study of osteoblast (OB) metabolism has recently received increased attention due to the considerable amount of energy used during the bone remodeling process. In addition to glucose, the main nutrient for the osteoblast lineages, recent data highlight the importance of amino acid and fatty acid metabolism in providing the fuel necessary for the proper functioning of OBs. Among the amino acids, it has been reported that OBs are largely dependent on glutamine (Gln) for their differentiation and activity. In this review, we describe the main metabolic pathways governing OBs' fate and functions, both in physiological and pathological malignant conditions. In particular, we focus on multiple myeloma (MM) bone disease, which is characterized by a severe imbalance in OB differentiation due to the presence of malignant plasma cells into the bone microenvironment. Here, we describe the most important metabolic alterations involved in the inhibition of OB formation and activity in MM patients.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24054893