Hydroxyapatite phagocytosis by human polymorphonuclear leucocytes

Hydroxyapatite crystals were incubated with human polymorphonuclear leucocytes and samples examined by light and electron microscopy after 3, 8, 30, and 120 minutes' incubation. Phagocytosis of crystals occurred at 3 minutes and increased with incubation. Degranulation of neutrophils, loss of c...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1979-02, Vol.38 (1), p.84-88
Main Authors: Maurer, K H, Schumacher, H R
Format: Article
Language:English
Subjects:
Humans
Hydroxyapatites - pharmacology
Microscopy, Electron
Neutrophils - drug effects
Neutrophils - physiology
Neutrophils - ultrastructure
Phagocytosis
Time Factors
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Description
Summary:Hydroxyapatite crystals were incubated with human polymorphonuclear leucocytes and samples examined by light and electron microscopy after 3, 8, 30, and 120 minutes' incubation. Phagocytosis of crystals occurred at 3 minutes and increased with incubation. Degranulation of neutrophils, loss of cytoplasmic density, and cell necrosis were greatest in cells mixed with apatite and increased with time. Avid in vitro phagocytosis of hydroxyapatite crystals lends further support to the potential of these crystals as causes of human arthritis.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.38.1.84