Tuberculosis Diagnosis and Preventive Monotherapy Among Children and Adolescents Exposed to Rifampicin-Resistant Tuberculosis in the Household

Abstract Background Children and adolescents with household exposure to multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB) are at high risk of developing TB disease. Tuberculosis preventive therapy (TPT) is recommended, but programmatic experience is limited, particularly for adolescents. M...

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Published in:Open forum infectious diseases 2023-03, Vol.10 (3), p.ofad087-ofad087
Main Authors: Apolisi, Ivy, Cox, Helen, Tyeku, Nolitha, Daniels, Johnny, Mathee, Shaheed, Cariem, Rabia, Douglas-Jones, Bianca, Ngambu, Noluvo, Mudaly, Vanessa, Mohr-Holland, Erika, Isaakidis, Petros, Pfaff, Colin, Furin, Jennifer, Reuter, Anja
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Language:English
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Summary:Abstract Background Children and adolescents with household exposure to multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB) are at high risk of developing TB disease. Tuberculosis preventive therapy (TPT) is recommended, but programmatic experience is limited, particularly for adolescents. Methods We conducted a prospective cohort study to describe MDR/RR-TB diagnosis and TPT provision for individuals aged
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofad087