Acute poststreptococcal glomerulonephritis in Maracaibo. II: Studies on the incidence, nature, and significance of circulating anti-immunoglobulins

Antiglobulins were measured in the sera of 82 patients with acute poststreptococcal glomerulonephritis and correlated with C1q binding activity, serum levels of immunoglobulins and C3, site of infection, antibody titres to streptococcal enzymes, and the duration of the nephritis and interval from in...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1979-06, Vol.38 (3), p.257-261
Main Authors: McIntosh, R M, Rabideau, D, Allen, J E, Garcia, R, Rubio, L, Carr, R I, Rodriguez-Iturbe, B
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Antibodies, Anti-Idiotypic - analysis
Child
Child, Preschool
Glomerulonephritis - etiology
Glomerulonephritis - immunology
Humans
Immunoglobulins - analysis
Immunoglobulins - immunology
Rheumatoid Factor - analysis
Streptococcal Infections - complications
Time Factors
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Summary:Antiglobulins were measured in the sera of 82 patients with acute poststreptococcal glomerulonephritis and correlated with C1q binding activity, serum levels of immunoglobulins and C3, site of infection, antibody titres to streptococcal enzymes, and the duration of the nephritis and interval from infection. Raised serum antiglobulins were found in 89.2% of the patients. In addition, raised titres were detected at any time during the course of the disease and very early after streptococcal infection. The finding of antiglobulins soon after the infection suggests the possibility that they appear as a primary event in the disease.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.38.3.257