Investigating Variation in Compressional Behavior of a Ternary Mixture from a Plastic, Elastic and Brittle Fracture Perspective in the Context of Optimum Composition of a Pharmaceutical Blend

The choice of optimum composition of a mixture of binary and ternary excipients for optimum compressional properties was investigated in this work. Excipients were chosen based on three types of excipients: plastic, elastic, and brittle fracture. Mixture compositions were selected based on a one-fac...

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Bibliographic Details
Published in:Polymers 2023-02, Vol.15 (5), p.1063
Main Authors: Ali, Hiba Hani Mohammed, Al-Akayleh, Faisal, Al Jafari, Abdel Hadi, Rashid, Iyad
Format: Article
Language:English
Subjects:
Analgesics
Analysis
Binary mixtures
Brittle fracture
Cellulose
Composition
Compressive properties
Context
Crystalline cellulose
Deformation
Design analysis
Design factors
Design of experiments
Excipients
Identification and classification
Lactose
Magnesium silicates
Mechanical properties
Methods
Optimization
Pharmaceuticals
Response surface methodology
Response surfaces (Statistics)
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Summary:The choice of optimum composition of a mixture of binary and ternary excipients for optimum compressional properties was investigated in this work. Excipients were chosen based on three types of excipients: plastic, elastic, and brittle fracture. Mixture compositions were selected based on a one-factor experimental design using the response surface methodology technique. Compressive properties comprising Heckel and Kawakita parameters, work of compression, and tablet hardness were measured as the main responses of this design. The one-factor RSM analysis revealed that there exist specific mass fractions that are associated with optimum responses for binary mixtures. Furthermore, the RSM analysis of the 'mixture' design type for the three components revealed a region of optimal responses around a specific composition. The foregoing had a mass ratio of 80:15:5 for microcrystalline cellulose: starch: magnesium silicate, respectively. Upon comparison using all RSM data, ternary mixtures were found to perform better in compression and tableting properties than binary mixtures. Finally, the finding of an optimal mixture composition has proven effective in its applicability in the context of the dissolution of model drugs (metronidazole and paracetamol).
ISSN:2073-4360
2073-4360
DOI:10.3390/polym15051063