Synthesis of Alginate Nanoparticles Using Hydrolyzed and Enzyme-Digested Alginate Using the Ionic Gelation and Water-in-Oil Emulsion Method

Alginate nanoparticles (AlgNPs) are attracting increasing interest for a range of applications because of their good biocompatibility and their ability to be functionalized. Alginate is an easily accessible biopolymer which is readily gelled by the addition of cations such as calcium, facilitating a...

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Bibliographic Details
Published in:Polymers 2023-03, Vol.15 (5), p.1319
Main Authors: Van Bavel, Nicolas, Lewrenz, Anna-Marie, Issler, Travis, Pang, Liping, Anikovskiy, Max, Prenner, Elmar J
Format: Article
Language:English
Subjects:
Alginates
Analysis
Biocompatibility
Biopolymers
Calcium chloride
Dispersion
Emulsification
Enzymes
Ethanol
Gelation
Homogeneity
Homogenization
Mass spectrometry
Methods
Micelles
Nanoparticles
Polymers
Production methods
Scientific imaging
Sodium
Surfactants
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Summary:Alginate nanoparticles (AlgNPs) are attracting increasing interest for a range of applications because of their good biocompatibility and their ability to be functionalized. Alginate is an easily accessible biopolymer which is readily gelled by the addition of cations such as calcium, facilitating a cost-effective and efficient production of nanoparticles. In this study, AlgNPs based on acid hydrolyzed and enzyme-digested alginate were synthesized by using ionic gelation and water-in-oil emulsification, with the goal to optimize key parameters to produce small uniform ( 0.10 mg/mL resulted in sizes > 200 nm with relatively high dispersity. Sonication in lieu of magnetic stirring proved to further reduce size and increase homogeneity of the nanoparticles. In the water-in-oil emulsification method, nanoparticle growth was confined to inverse micelles in an oil phase, resulting in lower dispersity. Both the ionic gelation and water-in-oil emulsification methods were suitable for producing small uniform AlgNPs that can be further functionalized as required for various applications.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym15051319