Therapeutic Efficacy of Polymeric Biomaterials in Treating Diabetic Wounds-An Upcoming Wound Healing Technology

Diabetic wounds are one of the serious, non-healing, chronic health issues faced by individuals suffering from diabetic mellitus. The distinct phases of wound healing are either prolonged or obstructed, resulting in the improper healing of diabetic wounds. These injuries require persistent wound car...

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Bibliographic Details
Published in:Polymers 2023-02, Vol.15 (5), p.1205
Main Authors: Sathyaraj, Weslen Vedakumari, Prabakaran, Lokesh, Bhoopathy, Jayavardhini, Dharmalingam, Sankari, Karthikeyan, Ramadoss, Atchudan, Raji
Format: Article
Language:English
Subjects:
Amputation
Biological products
Biomedical materials
Care and treatment
Collagen
Cytokines
Diabetes
Effectiveness
Extracellular matrix
Exudation
Fibroblasts
Growth factors
Health aspects
Hydrogels
Injury prevention
Metabolism
Microorganisms
Moisture content
Neutrophils
Review
Wound healing
Wounds and injuries
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Summary:Diabetic wounds are one of the serious, non-healing, chronic health issues faced by individuals suffering from diabetic mellitus. The distinct phases of wound healing are either prolonged or obstructed, resulting in the improper healing of diabetic wounds. These injuries require persistent wound care and appropriate treatment to prevent deleterious effects such as lower limb amputation. Although there are several treatment strategies, diabetic wounds continue to be a major threat for healthcare professionals and patients. The different types of diabetic wound dressings that are currently used differ in their properties of absorbing wound exudates and may also cause maceration to surrounding tissues. Current research is focused on developing novel wound dressings incorporated with biological agents that aid in a faster rate of wound closure. An ideal wound dressing material must absorb wound exudates, aid in the appropriate exchange of gas, and protect from microbial infections. It must support the synthesis of biochemical mediators such as cytokines, and growth factors that are crucial for faster healing of wounds. This review highlights the recent advances in polymeric biomaterial-based wound dressings, novel therapeutic regimes, and their efficacy in treating diabetic wounds. The role of polymeric wound dressings loaded with bioactive compounds, and their in vitro and in vivo performance in diabetic wound treatment are also reviewed.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym15051205