Hypothyroidism associated with mixed connective tissue disease and its response to steroid therapy

The case is reported of a 49-year-old housewife who presented with arthralgia and severe Raynaud's phenomenon. A diagnosis of mixed connective tissue disease (MCTD) was made on the basis of the clinical picture and serological findings. During the course of her disease she developed hypothyroid...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1981-06, Vol.40 (3), p.315-316
Main Authors: Withrington, R H, Seifert, M H
Format: Article
Language:English
Subjects:
Female
Humans
Hypothyroidism - complications
Hypothyroidism - drug therapy
Middle Aged
Mixed Connective Tissue Disease - complications
Prednisolone - therapeutic use
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Summary:The case is reported of a 49-year-old housewife who presented with arthralgia and severe Raynaud's phenomenon. A diagnosis of mixed connective tissue disease (MCTD) was made on the basis of the clinical picture and serological findings. During the course of her disease she developed hypothyroidism. She was started on prednisolone to control the symptoms of the MCTD, and after this her thyroid function returned to normal despite her never having had any thyroid replacement therapy. There is reported evidence that Hashimoto's thyroiditis responds to systemic steroid preparations, but we can find no report of hypothyroidism in MCTD having a similar response.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.40.3.315