Enhanced bacterial phagocytosis by peripheral blood monocytes in rheumatoid arthritis

To assess the functional state of peripheral blood monocytes in rheumatoid arthritis, we have measured phagocytosis of Staphylococcus aureus and Proteus mirabilis in 48 patients and 28 controls. Using radiolabelled bacteria preopsonised in normal human serum we have demonstrated significantly enhanc...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1984-06, Vol.43 (3), p.435-439
Main Authors: Steven, M M, Lennie, S E, Sturrock, R D, Gemmell, C G
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Rheumatoid - immunology
Biological and medical sciences
Blood Bactericidal Activity
Diseases of the osteoarticular system
Female
Humans
Inflammatory joint diseases
Male
Medical sciences
Middle Aged
Monocytes - immunology
Phagocytosis
Proteus mirabilis
Proteus mirabilis - immunology
Staphylococcus aureus - immunology
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Summary:To assess the functional state of peripheral blood monocytes in rheumatoid arthritis, we have measured phagocytosis of Staphylococcus aureus and Proteus mirabilis in 48 patients and 28 controls. Using radiolabelled bacteria preopsonised in normal human serum we have demonstrated significantly enhanced uptake of both organisms by patients' monocytes: (Median % uptake Staph. aureus: patients = 35.8; controls = 19.3; p less than 0.001. Median % uptake P. mirabilis: patients = 32.3; controls = 19.8; p less than 0.01.) These results indicate that patients' monocytes exist in an activated state, which may be important in the pathogenesis of rheumatoid arthritis.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.43.3.435