Drug resistance in human helminths : Current situation and lessons from livestock

In this review the available reports on drug resistance in human helminths, particularly hookworms and schistosomes, are critically analyzed. The experiences with helminths of livestock are then reviewed, in particular the factors contributing to the development of anthelmintic resistance, the mecha...

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Bibliographic Details
Published in:Clinical microbiology reviews 2000-04, Vol.13 (2), p.207-222
Main Authors: GEERTS, S, GRYSEELS, B
Format: Article
Language:English
Subjects:
Animals
Animals, Domestic
Anthelmintics - pharmacology
Anthelmintics - therapeutic use
Biological and medical sciences
Drug Resistance - genetics
Helminthiasis - drug therapy
Helminthiasis - parasitology
Helminthiasis, Animal - drug therapy
Helminthiasis, Animal - parasitology
Helminthic diseases
Helminths - drug effects
Helminths - genetics
Humans
Infectious diseases
Medical sciences
Miscellaneous
Parasitic diseases
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Summary:In this review the available reports on drug resistance in human helminths, particularly hookworms and schistosomes, are critically analyzed. The experiences with helminths of livestock are then reviewed, in particular the factors contributing to the development of anthelmintic resistance, the mechanisms and genetics of resistance to various anthelmintic classes, and the methods available for detection. These experiences appear to be worryingly similar and relevant to the potential development of drug resistance in human helminths. Recommendations to reduce its risks are suggested.
ISSN:0893-8512
1098-6618
DOI:10.1128/cmr.13.2.207