Sense of meaning and purpose in life and risk of incident dementia: New data and meta-analysis

Purpose: A greater sense of meaning and purpose in life is associated with lower dementia risk. The present research examines meaning and incident dementia in the largest sample to date, the UK Biobank, and combines the findings with the published literature on meaning/purpose and dementia risk in a...

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Published in:Archives of gerontology and geriatrics 2023-02, Vol.105, p.104847-104847, Article 104847
Main Authors: Sutin, Dr. Angelina R, Luchetti, Martina, Aschwanden, Damaris, Stephan, Yannick, Sesker, Amanda A., Terracciano, Antonio
Format: Article
Language:English
Subjects:
Aged
Alzheimer's disease
Biological Specimen Banks
Cognition
Dementia - epidemiology
Humans
Meaning in life
meta-analysis
prospective
Psychological Well-Being
Purpose in life
United Kingdom
vascular dementia
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Summary:Purpose: A greater sense of meaning and purpose in life is associated with lower dementia risk. The present research examines meaning and incident dementia in the largest sample to date, the UK Biobank, and combines the findings with the published literature on meaning/purpose and dementia risk in a meta-analysis. Method: Participants from the UK Biobank reported on their meaning in life in the 2016/2017 mental health assessment (N=153,445). All-cause and cause-specific dementia were derived from hospital and death records through November 2021. Cox regression was used to test the association between meaning in life and risk of incident dementia. Results from the UK Biobank were combined with published studies identified through a systematic literature review in a random-effect meta-analysis (k=8; total N=214,270). Results: UK Biobank participants were followed up to five years after their assessment of meaning in life; 551 participants developed dementia. For every one-point higher feeling of meaning, there was a 35% decreased risk of all-cause dementia (HR=.74, 95% CI=.67-.82, p
ISSN:0167-4943
1872-6976
DOI:10.1016/j.archger.2022.104847