Prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction

We sought to assess if COVID-19 infection recovery is associated with increased rates of newly diagnosed erectile dysfunction. Using IBM MarketScan, a commercial claims database, men with prior COVID-19 infection were identified using ICD-10 diagnosis codes. Using this cohort along with an age-match...

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Bibliographic Details
Published in:International journal of impotence research 2024-08, Vol.36 (5), p.521-525
Main Authors: Hebert, Kevin J., Matta, Rano, Horns, Joshua J., Paudel, Niraj, Das, Rupam, McCormick, Benjamin J., Myers, Jeremy B., Hotaling, James M.
Format: Article
Language:English
Subjects:
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Age
Bladder cancer
Body mass index
Cardiovascular disease
COVID-19
Diabetes
Erectile dysfunction
Hyperlipidemia
Hypertension
Infections
Longitudinal studies
Medicine
Medicine & Public Health
Population
Prostate cancer
Reproductive Medicine
rology
Spinal cord injuries
Urology
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Summary:We sought to assess if COVID-19 infection recovery is associated with increased rates of newly diagnosed erectile dysfunction. Using IBM MarketScan, a commercial claims database, men with prior COVID-19 infection were identified using ICD-10 diagnosis codes. Using this cohort along with an age-matched cohort of men without prior COVID-19 infection, we assessed the incidence of newly diagnosed erectile dysfunction. Covariates were assessed using a multivariable model to determine association of prior COVID-19 infection with newly diagnosed erectile dysfunction. 42,406 men experienced a COVID-19 infection between January 2020 and January 2021 of which 601 (1.42%) developed new onset erectile dysfunction within 6.5 months follow up. On multivariable analysis while controlling for diabetes, cardiovascular disease, smoking, obesity, hypogonadism, thromboembolism, and malignancy, prior COVID-19 infection was associated with increased risk of new onset erectile dysfunction (HR 1.27; 95% CI 1.1–1.5; P  = 0.002). Prior to the widespread implementation of the COVID-19 vaccine, the incidence of newly diagnosed erectile dysfunction is higher in men with prior COVID-19 infection compared to age-matched controls. Prior COVID-19 infection was associated with a 27% increased likelihood of developing new-onset erectile dysfunction when compared to those without prior infection.
ISSN:0955-9930
1476-5489
1476-5489
DOI:10.1038/s41443-023-00687-4