Systemic lupus erythematosus without clinical renal abnormalities: renal biopsy findings and clinical course

The extent and significance of renal biopsy abnormalities in patients with systemic lupus erythematosus (SLE) without clinical renal abnormalities is controversial. We report 11 consecutive SLE patients who were biopsied without clinical renal abnormalities. All 11 patients had mesangial changes eit...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1985-06, Vol.44 (6), p.415-419
Main Authors: O'Dell, J R, Hays, R C, Guggenheim, S J, Steigerwald, J C
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies - analysis
Biological and medical sciences
Biopsy
Complement System Proteins - metabolism
Creatinine - blood
DNA - immunology
Female
Fluorescent Antibody Technique
Follow-Up Studies
Glomerular Mesangium - pathology
Humans
Kidney - pathology
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - pathology
Male
Medical sciences
Middle Aged
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:The extent and significance of renal biopsy abnormalities in patients with systemic lupus erythematosus (SLE) without clinical renal abnormalities is controversial. We report 11 consecutive SLE patients who were biopsied without clinical renal abnormalities. All 11 patients had mesangial changes either by light microscopy or by immunofluorescent staining, and none had changes of focal or diffuse proliferative glomerulonephritis. Additionally none had deterioration of renal function during the mean follow-up period of 6.3 years.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.44.6.415