The link between post-traumatic stress disorder and systemic lupus erythematosus

• Published in: Brain, behavior, and immunity behavior, and immunity, 2023-02, Vol.108, p.292-301
• Main Authors: Goldschen, Lauren, Ellrodt, Jack, Amonoo, Hermioni L., Feldman, Candace H., Case, Siobhan M., Koenen, Karestan C., Kubzansky, Laura D., Costenbader, Karen H.
• Format: Article
• Language: English
• Subjects: Autoimmune; Cytokine; Genetic Predisposition to Disease; Humans; Hypothalamic-pituitary axis; Inflammation; Lupus Erythematosus, Systemic - complications; Post-traumatic stress disorder; Risk Factors; Stress Disorders, Post-Traumatic; Systemic lupus erythematosus
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2022.12.012

•Epidemiologic data support a link between PTSD and SLE-risk.•There is evidence of inflammation and immune system dysregulation in PTSD.•Inflammation that accompanies PTSD may fan the flames of smoldering SLE.•PTSD may be responsible for some of the disparities in SLE incidence and outcomes. Systemic lupus erythematosus (SLE) is a heterogeneous, multisystem autoimmune disorder characterized by unpredictable disease flares. Although the pathogenesis of SLE is complex, an epidemiologic link between posttraumatic stress disorder (PTSD) and the development of SLE has been identified, suggesting that stress-related disorders alter the susceptibility to SLE. Despite the strong epidemiologic evidence connecting PTSD and SLE, gaps remain in our understanding of how the two may be connected. Perturbations in the autonomic nervous system, neuroendocrine system, and at the genomic level may cause and sustain immune dysregulation that could lower the threshold for the development and propagation of SLE. We first describe shared risk factors for SLE and PTSD. We then describe potential biological pathways which may facilitate excessive inflammation in the context of PTSD. Among those genetically predisposed to SLE, systemic inflammation that accompanies chronic stress may fan the flames of smoldering SLE by priming immune pathways. Further studies on the connection between trauma and inflammation will provide important data on pathogenesis, risk factors, and novel treatments for SLE.