A study of anti-poly (ADP-ribose) antibodies and an anti-DNA antibody idiotype and other immunological abnormalities in lupus family members

The genetic background of systemic lupus erythematosus (SLE) has been reexamined in a study of the serum of 31 lupus patients and 80 asymptomatic first degree relatives by measuring a common, cross reacting anti-DNA antibody idiotype designated 134, antibodies to poly(ADP-ribose), serum C3, circulat...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1986-06, Vol.45 (6), p.502-507
Main Authors: Dudeney, C, Shoenfeld, Y, Rauch, J, Jones, M, Mackworth Young, C, Tavassoli, M, Shall, S, Isenberg, D A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies - genetics
Antibodies - immunology
Antibodies, Antinuclear - genetics
Antigen-Antibody Complex - genetics
Antigen-Antibody Complex - immunology
Biological and medical sciences
Child
DNA - genetics
DNA - immunology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin Idiotypes - genetics
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Male
Medical sciences
Middle Aged
Nucleoside Diphosphate Sugars - genetics
Poly Adenosine Diphosphate Ribose - genetics
Poly Adenosine Diphosphate Ribose - immunology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:The genetic background of systemic lupus erythematosus (SLE) has been reexamined in a study of the serum of 31 lupus patients and 80 asymptomatic first degree relatives by measuring a common, cross reacting anti-DNA antibody idiotype designated 134, antibodies to poly(ADP-ribose), serum C3, circulating immune complexes, and antinuclear antibodies (ANA). Over 30% of the relatives had raised 134 and anti-poly(ADP-ribose) levels, and 9% had ANA titres greater than 1/20. In contrast, only one relative had a low serum C3 level. These results confirm that immunogenetic abnormalities associated with the production of autoantibodies and particular idiotypes must exist amongst lupus relatives as well as the patients. The production of autoantibodies, however, is not necessarily matched to the clinical expression of SLE.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.45.6.502