Immunoglobulin A and C reactive protein levels in ankylosing spondylitis

Correspondence: SIR, We read with interest the recent paper by Sanders et al on the correlation of immunoglobulin and C reactive protein (CRP) levels in 22 patients with ankylosing spondylitis (AS) and 20 patients with rheumatoid arthritis (RA).' The authors found that IgA serum levels, though...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1987-09, Vol.46 (9), p.719-720
Main Authors: Collado, A, Sanmarti, R, Brancós, M A, Kanterewicz, E, Gallart, T, Rotés-Querol, J, Cobos, A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Ankylosing spondylitis
C-Reactive Protein - analysis
Espondiloartritis anquilosant
Female
Humans
Immunoglobulin A - analysis
Immunoglobulines
Immunoglobulins
Male
Middle Aged
Spondylitis, Ankylosing - immunology
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Summary:Correspondence: SIR, We read with interest the recent paper by Sanders et al on the correlation of immunoglobulin and C reactive protein (CRP) levels in 22 patients with ankylosing spondylitis (AS) and 20 patients with rheumatoid arthritis (RA).' The authors found that IgA serum levels, though raised in AS, do not correlate with CRP levels as they do in RA, suggesting that the mechanism of increase of IgA in the two diseases may be different. They conclude that production of IgA in AS is unrelated to the stimulation of acute phase reactants, reflecting a specific mucosal immune stimulation, possibly in the gut. Thus IgA may be a marker of the pathogenesis of AS.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.46.9.719