TNFSF15 and MIA Variant Associated with Immunotherapy and Prognostic Evaluation in Esophageal Cancer

Background. Esophageal cancer (ESCA) is a common gastrointestinal tumor, and China is one of the regions with a high incidence. Tumor immune-related cells play important roles in the tumorigenesis and development of ESCA. However, the role of tumor immune-related genes in the development of ESCA has...

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Bibliographic Details
Published in:Journal of oncology 2023, Vol.2023, p.1248024-12
Main Authors: You, Jun, Bian, Jiaojiao, Chen, Jian, Xia, Tianqin, Deng, Ailu, Zhang, Ming, Liao, YiChen, Wen, Huling, Xu, Zhengmin
Format: Article
Language:English
Subjects:
Analysis
Cancer
Cancer therapies
Dendritic cells
Drug therapy
Esophageal cancer
Gastrointestinal diseases
Gene expression
Genes
Genetic aspects
Genomes
Immunotherapy
Lymphocytes
Medical prognosis
Mortality
Mutation
Patients
Software
T cells
Tumorigenesis
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Summary:Background. Esophageal cancer (ESCA) is a common gastrointestinal tumor, and China is one of the regions with a high incidence. Tumor immune-related cells play important roles in the tumorigenesis and development of ESCA. However, the role of tumor immune-related genes in the development of ESCA has not been established. Methods. In this study, weighted gene coexpression network analysis (WGCNA) was used to analyze ESCA gene expression using data from The Cancer Genome Atlas (TCGA) database. Gene expression was associated with clinical traits, and modules related to CD8+T cells, dendritic cells, and regulatory T cells (Tregs) were obtained. Results. The GO analysis showed that inflammatory chemotaxis networks were activated by cell chemotaxis, chemokine activity, and chemokine binding receptor. Three hub genes (IL17C, TNFSF15, and MIA) related to tumor immunity and metastasis were identified by WGCNA, and the abnormal expression of each hub gene in ESCA has a poor prognosis, especially in patients with high expression (P
ISSN:1687-8450
1687-8450
DOI:10.1155/2023/1248024