Gram-negative bacilli carrying mcr gene in Brazil: a pathogen on the rise

The incidence of infections caused by resistant Gram-negative pathogens has become a critical factor in public health due to the limitation of therapeutic options for the control of infections caused, especially, by Enterobacteriaceae ( Escherichia coli and Klebsiella pneumoniae ), Pseudomonas spp.,...

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Bibliographic Details
Published in:Brazilian journal of microbiology 2023-06, Vol.54 (2), p.1009-1020
Main Authors: Costa-Júnior, Sérgio Dias, Ferreira, Ylanna Larissa Alves, Agreles, Maria Anndressa Alves, Alves, Álisson Emannuel Franco, Melo de Oliveira, Maria Betânia, Cavalcanti, Isabella Macário Ferro
Format: Article
Language:English
Subjects:
Antimicrobial agents
Bacteria
Biomedical and Life Sciences
Colistin
Conjugation
E coli
Environmental Microbiology - Review
Food Microbiology
Gram-negative bacilli
Health risks
Klebsiella
Life Sciences
Literature reviews
Medical Microbiology
Microbial Ecology
Microbial Genetics and Genomics
Microbiology
Multidrug resistance
Mycology
Pathogens
Plasmids
Polymyxins
Public health
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Summary:The incidence of infections caused by resistant Gram-negative pathogens has become a critical factor in public health due to the limitation of therapeutic options for the control of infections caused, especially, by Enterobacteriaceae ( Escherichia coli and Klebsiella pneumoniae ), Pseudomonas spp., and Acinetobacter spp. Thus, given the increase in resistant pathogens and the reduction of therapeutic options, polymyxins were reintroduced into the clinic. As the last treatment option, polymyxins were regarded as the therapeutic key, since they were one of the few classes of antimicrobials that had activity against multidrug-resistant Gram-negative bacilli. Nonetheless, over the years, the frequent use of this antimicrobial has led to reports of resistance cases. In 2015, mcr ( mobile colistin resistanc e), a colistin resistance gene, was described in China. Due to its location on carrier plasmids, this gene is characterized by rapid spread through conjugation. It has thus been classified as a rising threat to public health worldwide. In conclusion, based on several reports that show the emergence of mcr in different regional and climatic contexts and species of isolates, this work aims to review the literature on the incidence of the mcr gene in Brazil in different regions, types of samples identified, species of isolates, and type of carrier plasmid.
ISSN:1517-8382
1678-4405
DOI:10.1007/s42770-023-00948-w