Prognostic Value of IMP3 and Its Role as an Epithelial-Mesenchymal Transition Promoter in Breast Carcinoma

Breast carcinoma is now the most common cancer in the world. In view of its high mortality, there is a need to identify new prognostic biomarkers. Both IMP3 and SLUG have been implicated in cancer metastasis. This was a retrospective study conducted on 60 breast carcinoma cases using tissue microarr...

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Bibliographic Details
Published in:Indian journal of surgical oncology 2023-09, Vol.14 (3), p.659-667
Main Authors: Jha, Tanvi, Diwaker, Preeti, Arora, Vinod Kumar, Sharma, Sonal
Format: Article
Language:English
Subjects:
Breast cancer
Cancer surgery
Medicine
Medicine & Public Health
Oncology
Original
Original Article
Surgery
Surgical Oncology
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Summary:Breast carcinoma is now the most common cancer in the world. In view of its high mortality, there is a need to identify new prognostic biomarkers. Both IMP3 and SLUG have been implicated in cancer metastasis. This was a retrospective study conducted on 60 breast carcinoma cases using tissue microarrays. Demographic and clinicopathological details were recorded. Immunohistochemistry for IMP3 and SLUG was performed and evaluated in terms of percentage-cell-positivity and intensity of staining. A proforma was used to store data and was analyzed using SPSS v20. IMP3 positivity was found in 87% breast carcinoma cases and was significantly associated with tumor size ( p = 0.03) and TNM stage ( p = 0.024). IMP3 staining intensity showed significant association with histological grade ( p = 0.009), TNM stage ( p = 0.036), and molecular subtype ( p = 0.03). SLUG immunoexpression was seen in 90% breast carcinoma cases and was significantly associated with TNM stage ( p = 0.006). SLUG staining intensity was significantly associated with age ( p = 0.025) and TNM stage ( p = 0.004). IMP3 and SLUG immunopositivity and their staining intensities were significantly associated ( p
ISSN:0975-7651
0976-6952
DOI:10.1007/s13193-023-01735-7