Hypocalcemia after parathyroidectomy in patients taking proton pump inhibitors

• Published in: American journal of otolaryngology 2023-03, Vol.44 (2), p.103761-103761, Article 103761
• Main Authors: Lorenz, F. Jeffrey, Goldenberg, David
• Format: Article
• Language: English
• Subjects: Calcium; Humans; Hypocalcemia; Hypocalcemia - epidemiology; Hypocalcemia - etiology; Parathyroidectomy; Parathyroidectomy - adverse effects; Postoperative Complications - epidemiology; Postoperative Complications - etiology; PPIs; Proton pump inhibitors; Proton Pump Inhibitors - adverse effects; Retrospective Studies; Risk Factors
• ISSN: 0196-0709; 1532-818X
• DOI: 10.1016/j.amjoto.2022.103761

Long-term use of proton pump inhibitors is associated with metabolic derangements, including hypocalcemia. Hypocalcemia is also a known complication of parathyroidectomy. We sought to determine the rate of hypocalcemia following parathyroidectomy in patients on proton pump inhibitors. The TriNetX Research Network was queried to identify patients with a history of primary hyperparathyroidism treated with parathyroidectomy between 2012 and 2022. The incidence of short-term (0–6 months following parathyroidectomy) and permanent (6–12 months following parathyroidectomy) postoperative hypocalcemia was compared between patients using proton pump inhibitors and those who were not. Of 34,595 total patients, 19.5 % (n = 6753) were taking proton pump inhibitors prior to surgery. Patients taking proton pump inhibitors were significantly more likely to experience both short-term (RR, 95 % CI, P) (1.5, 1.4–1.6, P