Assessment of the levels of termination of the conus medullaris and thecal sac in the pediatric population

• Published in: Neuroradiology 2023-04, Vol.65 (4), p.835-843
• Main Authors: Blaaza, Mohammed, Figueira, Carolina Filipa Chaves, Ramali, Mohamed Rashad, McNamara, Cillian, Severino, Mariasavina, Tortora, Domenico, Mankad, Kshitij, Rossi, Andrea
• Format: Article
• Language: English
• Subjects: Age; Age composition; Child; Congenital defects; Dura Mater; Gender; Humans; Imaging; Infant; Italy; Magnetic Resonance Imaging - methods; Medicine; Medicine & Public Health; Neural tube defects; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Normal distribution; Paediatric Neuroradiology; Pediatrics; Population studies; Radiology; Search algorithms; Sheaths; Spinal cord; Spinal Cord - diagnostic imaging; Spine; Statistical analysis
• ISSN: 0028-3940; 1432-1920
• DOI: 10.1007/s00234-022-03111-8

Purpose This study assessed the position of the termination of the conus medullaris (the point where the spinal cord tapers to an end) and thecal sac (the sheath of dura mater that surrounds the spinal cord and caudal nerve roots) in a large pediatric population, to characterise the nature of the pediatric Gaussian distribution and assess whether age affected the distribution. The study further aimed to assess the effect of gender on termination positions. Methods A total of 520 MRI spine studies of children aged between 1 month and 19 years old were collected from two pediatric tertiary referral centres in the UK and Italy. Studies with pathological findings were excluded, and normal scans were found using keyword search algorithms on a database of radiologists’ reports. The reported scans were individually assessed and reviewed by two experienced neuroradiologists. The termination points of the conus medullaris and thecal sac were determined for each study. Local IRB approvals were sought. Results The results showcased a Gaussian distribution in both conus medullaris ( r =0.8997) and thecal sac termination levels ( r =0.9639). No statistically significant results were noted with increasing age for the termination positions of the conus medullaris or thecal sac ( p = 0.154, 0.063). No statistical significance was observed with gender variation with either anatomical landmark. A weak positive correlation was observed between the termination levels of the conus medullaris and the thecal sac ( r =0.2567) Conclusion Termination levels across all pediatric age range followed a Gaussian distribution. Knowledge of normal termination levels has relevant clinical implications, including the assessment of patients with suspected spinal dysraphism.