Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids

The serum concentration of lipids and composition of fatty acids after overnight fasting were studied in 18 patients with rheumatoid arthritis treated for 12 weeks with either 20 ml of evening primrose oil containing 9% of gamma-linolenic acid or olive oil. The serum concentrations of oleic acid, ei...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1989-02, Vol.48 (2), p.124-127
Main Authors: Jäntti, J, Nikkari, T, Solakivi, T, Vapaatalo, H, Isomäki, H
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - drug therapy
Biological and medical sciences
Clinical Trials as Topic
Dietary Fats, Unsaturated - therapeutic use
Diseases of the osteoarticular system
Double-Blind Method
Fatty Acids - blood
Fatty Acids, Essential - therapeutic use
gamma-Linolenic Acid
Humans
Inflammatory joint diseases
Linoleic Acids
Lipids - blood
Medical sciences
Middle Aged
Olive Oil
Plant Oils - therapeutic use
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Summary:The serum concentration of lipids and composition of fatty acids after overnight fasting were studied in 18 patients with rheumatoid arthritis treated for 12 weeks with either 20 ml of evening primrose oil containing 9% of gamma-linolenic acid or olive oil. The serum concentrations of oleic acid, eicosapentaenoic acid, and apolipoprotein B decreased and those of linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, and arachidonic acid increased during treatment with evening primrose oil. During olive oil treatment the serum concentration of eicosapentaenoic acid decreased and those of high density lipoprotein-cholesterol and apolipoprotein A-I increased slightly. The decrease in serum eicosapentaenoic acid and the increase in arachidonic acid concentrations induced by evening primrose oil may not be favourable effects in patients with rheumatoid arthritis in the light of the roles of these fatty acids as precursors of eicosanoids.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.48.2.124