Successful Treatment of Basaloid Squamous Cell Carcinoma of the Nasal Cavity With Brain Invasion

Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive subtype of squamous cell carcinoma (SCC). To date, no consensus on the treatment of BSCC has been established yet, especially in cases of invasion of the skull base. In addition, long-term prognosis has not been reported in T4b cases....

Full description

Saved in:
Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-02, Vol.15 (2), p.e35293
Main Authors: Ii, Rieko, Nakayama, Masahiro, Tanaka, Shuho, Akutsu, Hiroyoshi, Tabuchi, Keiji
Format: Article
Language:English
Subjects:
Cancer
Case reports
Chemotherapy
Consciousness
Edema
Larynx
Magnetic resonance imaging
Medical prognosis
Necrosis
Neurosurgery
Otolaryngology
Patients
Radiation Oncology
Radiation therapy
Sinuses
Squamous cell carcinoma
Surgery
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive subtype of squamous cell carcinoma (SCC). To date, no consensus on the treatment of BSCC has been established yet, especially in cases of invasion of the skull base. In addition, long-term prognosis has not been reported in T4b cases. Herein, we report the case of a 36-year-old Japanese man with locally advanced nasal BSCC that directly invaded the skull base and the brain. The patient was then treated with induction chemotherapy (IC). Owing to his good response to IC, we planned and performed en bloc resection followed by adjuvant proton beam therapy (PBT). Follow-up examinations five years after treatment showed no evidence of recurrence. This is the first report of IC followed by radical surgery and adjuvant PBT in a patient with T4b. IC has the potential to play an important role in treatment strategies.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.35293