A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper( ii ) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assu...

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Bibliographic Details
Published in:RSC advances 2023-03, Vol.13 (14), p.9715-9719
Main Authors: Vieira, Eduardo Guimarães, Fazzi, Rodrigo Boni, Martins, Daniel O. T. A, Sheveleva, Alena M, Tuna, Floriana, da Costa Ferreira, Ana Maria
Format: Article
Language:English
Subjects:
Chemistry
Continuous radiation
Copper compounds
Electron paramagnetic resonance
Polyhedral oligomeric silsesquioxane
Spectroscopy
Toxicity
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Summary:A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper( ii ) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials. An oxindolimine-copper( ii ) complex with antitumor properties was immobilized in a silica matrix, and verified to be more active and selective due the formation of a dinuclear species, unveiled by continuous wave and pulsed EPR spectroscopy.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra07266a