Risk factors, clinical characteristics and prognostic value of acute kidney injury in COVID-19 compared with influenza virus and respiratory syncytial virus

Background Acute Kidney Injury (AKI) complicates a substantial part of patients with COVID-19. Direct viral penetration of renal cells through the Angiotensin Converting Enzyme 2 receptor, and indirect damage by the aberrant inflammatory response characteristic of COVID-19 are likely mechanisms. Nev...

Full description

Saved in:
Bibliographic Details
Published in:Journal of nephrology 2023-06, Vol.36 (5), p.1349-1359
Main Authors: Shusterman, Eden, Kliuk Ben-Bassat, Orit, Zahler, David, Kupershmidt, Aviv, Weiss-Meilik, Ahuva, Kehat, Orli, Ablin, Jacob N.
Format: Article
Language:English
Subjects:
Acute Kidney Injury - diagnosis
Acute Kidney Injury - epidemiology
Acute Kidney Injury - etiology
COVID-19 - complications
COVID-19 - epidemiology
Hospitalization
Humans
Influenza, Human - complications
Influenza, Human - diagnosis
Influenza, Human - epidemiology
Medicine
Medicine & Public Health
Nephrology
Original
Original Article
Orthomyxoviridae
Prognosis
Respiratory Syncytial Virus Infections - complications
Respiratory Syncytial Virus Infections - diagnosis
Respiratory Syncytial Virus Infections - epidemiology
Respiratory Syncytial Viruses
Retrospective Studies
Risk Factors
SARS-CoV-2
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Acute Kidney Injury (AKI) complicates a substantial part of patients with COVID-19. Direct viral penetration of renal cells through the Angiotensin Converting Enzyme 2 receptor, and indirect damage by the aberrant inflammatory response characteristic of COVID-19 are likely mechanisms. Nevertheless, other common respiratory viruses such as Influenza and Respiratory Syncytial Virus (RSV) are also associated with AKI. Methods We retrospectively compared the incidence, risk factors and outcomes of AKI among patients who were admitted to a tertiary hospital because of infection with COVID-19, influenza (A + B) or RSV. Results We collected data of 2593 patients hospitalized with COVID-19, 2041 patients with influenza and 429 with RSV. Patients affected by RSV were older, had more comorbidities and presented with higher rates of AKI at admission and within 7 days (11.7% vs. 13.3% vs. 18% for COVID-19, influenza and RSV, respectively p =  0.001). Nevertheless, patients hospitalized with COVID-19 had higher mortality (18% with COVID-19 vs. 8.6% and 13.5% for influenza and RSV, respectively P 
ISSN:1724-6059
1121-8428
1724-6059
DOI:10.1007/s40620-023-01591-2